TARGET-LIVER DISEASE
Leading real-world registry of liver disease patients regionally distributed and covering chronic conditions
Powering Liver Disease Research
TARGET-LIVER DISEASE (TARGET-LD) is the world's largest liver disease registry with a diverse patient population across the U.S. of over 600,000 patients with more than 15 million months of follow-up. This invaluable resource provides comprehensive data on disease activity, severity scores, procedures, comorbidities, medications, and more. By leveraging this rich data, researchers and clinicians can gain deeper insights into liver disease progression, treatment efficacy, and patient outcomes.
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600,000+ Patients
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50+ Sites
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15 Million Months of Follow-Up
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25+ Clinical Investigators
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65+ Publications
Complete Patient Journeys Creating a Fit-For-Purpose Dataset
TARGET-LD captures a comprehensive range of patient information including demographics, vital signs, medical history, procedures, imaging, and lab results to drive clinical research and understanding of real-world patients suffering from chronic liver disease. Target RWE curates and transforms clinically derived health data making it available for research to enhance the understanding of disease mechanisms and progression, diverse patient subgroups, clinical outcomes and treatment effectiveness.
Demographics
Detailed demographic data to support research on health disparities and impacts on diagnosis, treatment selection, treatment response and disease progression.
Example of Measures
Sex, Race, Ethnicity, Birth Year, 3 digit Zip, payer type, & years education
Vitals
These vital signs provide baseline information about a patient's overall health and can be used to assess disease severity and risk factors.
Example of Measures
Height, Weight, & Blood Pressure
Medications
Tracking medication usage patterns helps to understand treatment adherence, efficacy, and potential adverse events. This information is crucial for evaluating the real-world effectiveness of therapies.
Example of Measures
Medication start date, Medication stop date, & Medication dose
Procedures
Liver biopsy data provides valuable insights into the histopathological features of liver disease, including the presence and severity of fibrosis and inflammation.
Example of Measures
Liver Biopsy (date, steatohepatitis, steatosis, fibrosis staging)
Imaging
Imaging studies offer a visual assessment of liver structure, function, and disease progression. These data can be used to identify potential biomarkers and monitor treatment response.
Example of Measures
CT Scan, Ultrasound, and MRI (date, ascites, varices, collaterals, portal hypertension, splenomegaly, variceal bleeding), EGD (date, varices, portalgastropathy), & Fibroscan (date, liver stiffness measurement, CAP result, Fibrosis staging)
Labs
These tests provide information on liver function, inflammation, coagulation status, and overall metabolic health. They are essential for assessing disease severity, monitoring treatment response, and identifying potential side effects.
Example of Measures
WBC, Neutrophils, Lymphocytes, Hemoglobin, Platelet count, Serum ALT, Serum AST, Serum ASP, Gamma Glutamyl, Total Bilirubin, Direct Bilirubin, Albumin, Creatinine, Potassium, Sodium, LDL, HDL, Triglycerides, Total Cholesterol, Gamma globulin, Creatinine Clearance, & eGFR
Disease Activity & Severity Scores
Track the progression of liver disease across a variety of conditions, including Nonalcoholic Fatty Liver Disease (NAFLD), Primary Sclerosing Cholangitis (PSC), Cirrhosis, Primary Biliary Cholangitis (PBC), Alpha-1 Antitrypsin Deficiency, Wilson's Disease, Hepatitis C Virus (HCV), Hepatitis B Virus (HBV), and Hepatocellular Carcinoma (HCC).
Utilizing a combination of clinical data, laboratory tests, and imaging studies, we develop robust risk stratification algorithms and prognostic models. By incorporating data from liver biopsies, Fibroscans, and advanced fibrosis scores like APRI, FIB-4, ELF, BARD, SAFE Score, and NAFLD Fibrosis Score, Target RWE produces valuable insights into disease severity and progression. This comprehensive approach enables us to better understand the patient journey and identify potential therapeutic targets.
ALBI
APRI
MELD
Mayo Score
NAS
Globe Score
Child Pugh Score
NAFLD Fibrosis Score
ELF
BARD
SAFE Score
Milan Criteria
Proud Partners with the American Association for the Study of Liver Diseases (AASLD)
To accelerate the development of innovative therapies and improve patient outcomes in liver disease by leveraging real-world evidence and fostering collaboration between industry, academia, and clinical practice.
By collaborating with AASLD, TARGET-LD aims to leverage real-world data to improve patient outcomes and inform clinical practice. The registry’s extensive data supports the CQC initiative by enabling the identification of best practices and the development of evidence-based guidelines.
Learn MoreThe CQC partnership with AASLD has enrolled approximately 75,000 patients with various liver diseases, including MASLD, NASH, HBV, HCC, PBC, and PSC, enabling the study of disease progression and treatment outcomes.
Collaborating with Target RWE
Lead Liver Research
By joining TARGET-LD, investigators and sites become part of the largest, most comprehensive, and technologically advanced hepatology research consortium.
Collaborate with Experts and Access Advanced Tools
This unique opportunity allows for collaboration with leading experts in the field and access to cutting-edge research tools and technologies.
Personalized Data Insights
Receive interactive quarterly reports and CQC dashboards tailored to your site's specific data.
Accelerated Research
Utilize individual site data for clinical trial cohort development, preliminary grant submissions, and feasibility analyses.
Concept Development
Develop robust research concepts and refine study designs.
Data Access and Analysis
Gain cloud-based access to relevant data and analytical tools (R and Python) to conduct in-depth analyses.
Discover Hidden Insights
Uncover trends, patterns, and potential research avenues within a vast dataset.
Drive Your Research Forward
Refine research questions, identify eligible patients, and collaborate with peers.
Ready Partner with TARGET-LD to Advance Liver Disease Research?
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