TARGET-DERM
The largest longitudinal RWE study observing patients with immune-mediated inflammatory skin conditions
Advancing the Understanding of Dermatologic Conditions in the Real World
TARGET-DERM is a longitudinal, observational study which characterizes the natural history of patients with immune-mediated inflammatory skin conditions in the real world through an innovative collaboration of academic and community sites in the U.S. Target RWE has enrolled more than 7,000+ patients covering many disease areas including atopic dermatitis, alopecia areata, hidradenitis suppurativa, vitiligo, and chronic spontaneous urticaria.
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7,000+ Patients
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35+ Sites
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30+ Publications
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12+ Thought Leaders
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Patient-Reported Outcome Measure (PROM) Data
Complete Patient Journeys to Create a Fit-For-Purpose Dataset
Our extensive dermatology real-world data enables researchers to deepen their understanding of complex dermatologic conditions. Through detailed analysis of patient-level information, this robust study provides crucial insights into skin disease patterns, therapeutic effectiveness, and long-term clinical outcomes.
Medications
Detailed medication data, including current medications, medication history, and treatment sequencing, are captured. This comprehensive view of medication use allows for the study of treatment patterns, comparative effectiveness research, and the impact of polypharmacy on patients with dermatologic conditions.
Example of Measures
Medication name, dose, time on treatment, conmeds, IMISCs treatments, alternative IMISCs treatments, & reason for discontinuation.
Procedures
Information on all medical procedures, including skin biopsies, allergy testing, and patch testing, is included in TARGET-DERM. This data is essential for understanding the diagnostic pathways followed by patients, as well as for assessing the utilization and impact of various procedures on disease management.
Example of Measures
All procedures, allergy testing, patch testing, and skin biopsy.
Imaging
TARGET-DERM includes data from imaging procedures relevant to dermatological care. This information would allow for the correlation of visual findings with clinical assessments and patient-reported outcomes.
Example of Measures
vIGA-AD, total BSA, Hurley Staging System, HS-PGA (Hidradenitis Suppurativa Physician Global Assessment), & anatomical locations and flares.
Demographics
TARGET-DERM captures a wide range of demographic data, including age, sex, race, ethnicity, and geographic location. This information is crucial for understanding how these factors may influence disease prevalence, severity, and treatment response, allowing for analyses that address potential disparities in care and outcomes.
Example of Measures
Sex, race, ethnicity, birth year, three-digit ZIP, payer type, & years of education.
Labs
TARGET-DERM includes a wide array of laboratory data, such as CBC, chemistry panels, lipid panels, and other relevant labs. This information is critical for monitoring patients' overall health, identifying potential biomarkers, and understanding the relationship between systemic health and skin conditions.
Example of Measures
Complete Blood Count (CBC), chemistry panel, lipid panel, and other labs.
Disease Activity & Severity Scores
TARGET-DERM offers a robust platform for observational research in immune-mediated inflammatory skin conditions. Data curated from electronic medical records includes both structured and unstructured data, and is enriched by a collection of disease activity and severity measures, to provide a granular view of the patient journey.
By utilizing these standardized disease activity scores, researchers can assess the efficacy of new therapies, identify patient subgroups for targeted treatments, inform the design of clinical trials, and track long-term disease progression and potential complications.
Atopic Dermatitis
- vIGA-AD x BSA
- Eczema Area and Severity Index
- Serum, Whole Blood, Saliva, & Skin Tape Strips
Alopecia Areata
- SALT
- CGI-AA
- ClinRO for Eyebrow/Eyelash Hair loss
Hidradenitis Supparativa
- Hurley Staging System
- HS Physician Global Assessment
Patient-Reported Outcome Measures (PROMs)
In AD, PROMs capture the burden of itch, pain, sleep disturbance, and overall quality of life (QoL). Measures like the Patient-Oriented Eczema Measure (POEM), SCORing Atopic Dermatitis (SCORAD), and Dermatology Life Quality Index (DLQI) help quantify the subjective impact of AD, informing treatment strategies and highlighting areas where patient needs are unmet.
Example of Measures
DLQI, NRS-Pain, NRS-Sleep, PO-SCORAD, POEM, PROMIS (Anxiety, Itch, & Mood), & UKWPC
In AA, PROMs assess the psychological and emotional impact of hair loss, including anxiety, depression, and perceptions of hair regrowth or loss. The Alopecia Areata Patient-Reported Outcomes (AAPRO) and other relevant scales provide insights into how AA affects patients' well-being and daily life.
Example of Measures
AAPPO, AARU, PGIS-AA, PROMIS (Anxiety & Depression), & PSAT
In HS, PROMs like the DLQI and Hidradenitis Suppurativa International Quality of Life (HISQOL) tools capture the impact of pain, odor, drainage, and scarring on patients' QoL. These measures highlight the often-hidden burden of HS, emphasizing the need for holistic care that addresses both physical and psychosocial needs.
Example of Measures
DLQI, HiSQOL, HSIA, HSSI, Pt. Questionnaire, & PGA-Skin Pain
Collaborating with TARGET-DERM
Pioneering Dermatological Research
Be at the forefront of dermatological discovery with access to one of the most extensive and dynamic real-world data networks focused on immune-mediated skin conditions.
Partner with Experts & Utilize Cutting-Edge Analytics
Collaborate with renowned dermatologists and researchers, leverage advanced analytical tools and techniques, and contribute to groundbreaking research that transforms the understanding and treatment of skin diseases.
Translating Insights into Impact
TARGET-DERM empowers researchers to transform dermatological research concepts into impactful real-world studies.
Access Comprehensive Data & Advanced Analytics
Our platform provides access to a wealth of patient-level data and cutting-edge analytical tools designed specifically for dermatological research.
Explore TARGET-DERM Data
Our Data Explorer platform provides access to a rich repository of de-identified patient data, empowering your dermatological research.
Empower Your Research
Utilize our tools to explore patient-level data, refine your hypotheses, and identify specific cohorts for your studies.
Ready to Partner with TARGET-DERM to Advance Dermatological Research?
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