News & Events
Published On: 2/2/2021
Target RWE Shares Weight Loss Data From Ongoing NASH Study
Real-world study shows only 32% of overweight or obese adults with NAFLD in the U.S. achieved 5% or more weight reduction
DURHAM, N.C., Feb. 2, 2021 /PRNewswire/ -- Target RWE, a leading real-world evidence (RWE) solutions company for the pharmaceutical and biotech industries, shared the latest data from the ongoing TARGET-NASH observational study, published in Clinical Gastroenterology & Hepatology (https://doi.org/10.1016/j.cgh.2021.01.023).
The nonalcoholic steatohepatitis (NASH) study, Weight Loss and Weight Regain in Usual Clinical Practice: Results from the TARGET-NASH Observational Cohort, analyzed 2,019 patients enrolled in the TARGET-NASH cohort in the United States over a median follow-up of 39 months. The baseline characteristics included one third of patients classified as obesity class 2/3, 38.6% of patients had diabetes, and approximately 50% had documentation of lifestyle modifications or diet recommendations.
Over a median follow-up of 39 months, the study found the following results:
- 32% of patients had weight reduction of 5% or more;
- Median time to initial weight loss was shorter in patients who were obesity class 2/3; and
- Only 25% of patients maintained 5% or more weight loss.
"We know that obesity and metabolic syndrome are major risk factors for the development of nonalcoholic fatty liver disease (NAFLD), and its more severe form, NASH. Thus, lifestyle modifications such as weight reduction are a critical step in the treatment of the disease," said Miguel Malespin, MD, Transplant Hepatology Specialist, Tampa General Hospital, and lead author on the manuscript. "The results of weight loss and weight gain from the TARGET-NASH cohort can help inform future studies of management of NAFLD."
"Our analyses found that among those with initial weight loss, 21% regained weight back to baseline during follow-up, and 59% of those patients did so within the first year of weight loss," said Anna Lok, MD, Professor of Medicine, University of Michigan, and senior author. "These data have implications for identifying patient populations who are more or less likely to lose weight in the absence of pharmacological interventions and provide important background information for the interpretation of clinical trial results."
TARGET-NASH is a longitudinal study of adults and pediatric participants with NAFLD and/or NASH in usual clinical practice. Target RWE's NASH sites include 65 community and academic centers in the U.S. and Europe that have enrolled more than 5,700 participants to date. Three years of retrospective data is obtained at time of enrollment and patients are then followed prospectively for a minimum of 5 years, including patient-reported outcome measures and biospecimen samples.
About Target RWE
As the industry's best-in-class, complete real world evidence (RWE) solution, Target RWE is a distinctly collaborative enterprise that unifies real world data (RWD) sets and advanced RWE analytics in an integrated community, shifting the paradigm in healthcare for how decisions are made to improve lives.
Target RWE sources unique, connected data sets across multiple therapeutic areas representing granular data from diverse patients in academic and community settings. Our rigorous, interactive, and advanced RWE analytics extract deep insights from RWD to answer important questions in healthcare. Target RWE brings together the brightest minds in healthcare through an unmatched community of key opinion leaders, patients, and healthcare stakeholders in a collaborative and dynamic model. www.targetrwe.com
984.234.0268 ext 205
11/13/2023Real-World Evidence in Pharmaceutical Drug Development – Faster, Safer and More Relevant?
10/23/2023Leveraging Real-World Evidence with Analytics: 3 Essential Components to Capture a 360-Degree View of Your Patient Population
11/13/2023TARGET-NASH Offers Unprecedented Glimpse into Growing Public Health Concerns with Few Treatment Options
11/10/2023Target RWE Releases Important Updates on the Cirrhosis Quality Collaborative/TARGET-Liver Disease Partnership with the American Association for the Study of Liver Diseases
09/21/2023New Eosinophilic Gastrointestinal Disorders (EGIDs) Real World Registry Surpasses 1,000 Patient Milestone