Custom Analytics
With focus on modern epidemiological methods and statistical rigor, we excel in analyzing and visualizing data to meet the complex needs of our partners
How Can We Solve Your Research Question?
Our tools are agnostic to the type of data source, enabling use of claims, Target RWE registry data curated from structured and unstructured electronic health records, or other types of data to meet the partner’s study needs.
Treatment selection is affected by many factors associated with a patient’s prognosis, variable uptake in the marketplace, and channeling of treatments to specific patient populations, which can lead to bias when comparing treatment groups. Before embarking on a comparative safety or effectiveness analysis using real-world data, it is key for researchers to evaluate whether patients starting a treatment can be validly compared to patients starting a different medication. At Target RWE, we deploy advanced negative control outcome methods to assess if the comparative study can be conducted with minimal bias, avoiding the pitfalls of unnecessary studies or unexpected results.
Assessing the comparative effectiveness and safety of treatments is complex, especially with rapidly evolving disease characteristics and targeted patient subgroups. Target RWE excels in addressing these challenges using advanced methodologies, such as clone-censor-weight approaches, to deliver reliable comparative effectiveness studies. Our expertise helps answer critical questions about treatment outcomes, optimal timing for initiating treatments, and the comparative risks associated with different therapies. By leveraging our comprehensive real-world data and cutting-edge analytics, we enable precise decision-making and optimized treatment strategies.
Understanding healthcare utilization and expenditures is essential for effective decision-making. Target RWE’s custom analytics assess healthcare costs and treatment utilization patterns, overall and in subgroups of interest. Our advanced analytic services evaluate the long-term effectiveness, safety, and cost-effectiveness of interventions compared to other treatment options available in the market. By leveraging diverse real-world data sources, we help you make informed decisions that support value-based pricing strategies and optimize healthcare resource utilization, improving patient care and outcomes.
Utilizing our registry data or large claims data, Target RWE builds external control arm (ECA) studies comparable to a trial population. Our novel methodologies handle sparse or missing data before conducting a comparative analysis of outcomes between the trial arm and external control arm. Target RWE's bias quantification analyses ensure results are robust to unmeasured confounding. We additionally offer a clean room committee of experts to mitigate the potential of bias at study decision points. Discover how our ECA solutions can elevate your research and drive impactful healthcare innovations.
Custom Studies Leveraging Target RWE Registries
We offer nested and standalone studies leveraging our robust registries, infrastructure, and data collection methods providing efficient and cost-effective research solutions. Target RWE's innovative studies are designed to meet diverse needs including regulatory commitments, label enhancement and validation, external control arms, and comparative analysis.
Complex Subpopulation Research
Our nested studies are meticulously crafted to explore specific subpopulations within a parent disease cohort.
By jointly developing ancillary protocols with our partner, we address complex research questions or pharmacovigilance needs, ensuring comprehensive and targeted insights.
Flexibility and Control
Our standalone studies offer unparalleled flexibility and capitalize on our extensive network of sites and centralized infrastructure by incorporating standard-of-care and protocol-defined assessments.
Designed to meet the unique requirements of your research, these studies can include specialized data variables and additional features.
Methods
Clone-Censor-Weight Analysis
Clone-censor-weighting is a modern analytic approach that advances beyond traditional propensity-score matching and evaluates complex clinical questions concerning optimal management of disease over time. Target RWE has successfully implemented clone-censor-weighting methods across a range of therapeutic areas and patient populations. In the approach, patients are copied – or “cloned” – into one cohort per treatment protocol, allowing for the comparison of specific treatment sequences observed in the real world. In each cloned cohort, patients are then artificially censored when they deviate from treatment sequence under study and reweighted to reflect the original target population.
Predictive Modeling with Machine Learning
Predictive modeling using machine learning methods has many applications in healthcare; however, creating predictive models with healthcare data can present numerous challenges. Predictor variables of interest may not exist in data and require algorithms that may be subject to substantial measurement error. Missing and mismeasured data are common due to changes in insurance providers or inconsistent data collection, and most machine learning methods do not address missingness in covariates or outcomes. At Target RWE, we have proven experience using predictive modeling with claims data, including the development of empirically derived variables, variable screening, variable importance measures, Harrell C index, inverse probability of censoring weighting, regularized Cox regression, and survival trees.
Treatment Pattern Visualizations
Target RWE’s advanced analytical solutions offer comprehensive options for analyzing and visualizing treatment patterns for specific diseases. Our capabilities include tracking treatment uptake, comparing trends, and identifying patient phenotypes that predict outcomes. Key questions addressed include treatment patterns, variations across subgroups, cumulative incidence of treatment initiation, and predictors of discontinuation. These insights enable healthcare providers to understand treatment dynamics, make informed clinical decisions, and improve patient care. Our tools offer a nuanced view of treatment patterns, ensuring tailored interventions for optimal outcomes across diverse patient populations.
Time-to-Event Analyses
Time-to-event analyses are crucial in clinical research, providing accurate estimates of important outcomes like survival and disease progression while adjusting for biases such as death, dropout, and other factors. At Target RWE, our causalPHR™ tool enables partners to stratify and filter results by key patient clinical and demographic characteristics, offering a deeper exploration of data. This allows researchers to answer critical questions about median survival times and disease progression, helping to uncover variations based on patient demographics and geography.
Expert Guidance to Harness the Power of Real-World Data
At Target RWE, our advisory services offer unparalleled expertise in real-world evidence analytics, ensuring your research achieves the highest standards of accuracy and reliability.
Address Study Bias
Target RWE's Clean Room Committee, consisting of expert statisticians, epidemiologists, and clinicians, recommends protocol modifications without knowing their impact on analyses. This ensures impartiality. The committee reviews only aggregated or blinded data, maintaining a comprehensive audit trail of all activities and recommendations. Partner with Target RWE to leverage our rigorous Clean Room Committee process, ensuring scientific integrity.
Access a Vast Network of Sites
Our Coordinating Center is staffed by a dedicated team of experts, including epidemiologists, statisticians, and data specialists, ready to streamline your multi-source studies. We excel in harmonizing diverse data sets and protocols, ensuring seamless integration and consistency across all research components. Our team’s expertise and collaborative approach enable us to manage complex projects efficiently, providing you with cohesive, high-quality data insights. Trust Target RWE's Coordinating Center to elevate your research with precision and reliability, supporting your journey from data collection to impactful conclusions.
Support for Study Designs
Our team of expert epidemiologists and statisticians collaborates closely with partners through teleconferences and in-person meetings to provide comprehensive study design consulting. We offer guidance on a wide range of analyses, from basic descriptive statistics to the most advanced analytic methods. Our services include the development and application of R programming for sophisticated statistical analyses, ensuring robust and reliable results. Additionally, we provide consultation on study design and conceptualization, the application of advanced analytical methods, study operationalization, and the review and editing of study protocols, abstracts, and manuscripts.
KOLs to Ensure Study Integrity
Target RWE’s Adjudication Committee, a panel of distinguished disease experts, meticulously evaluates clinical events in our research studies to ensure unbiased, accurate, and comprehensive adjudication. This rigorous approach enhances the integrity and reliability of our study outcomes. For example, in our work with NASH drugs, the committee reviews critical endpoints like the reduction in hepatic decompensation events, providing validation that surpasses standard data aggregation methods. This ensures the true clinical benefit of treatments, supporting regulatory approval and effective patient therapies. Target RWE’s commitment to high-quality, unbiased adjudication sets a benchmark for excellence in real-world evidence research.
Host Epidemological Seminars
At Target RWE, our advanced analytics team offers a comprehensive Seminar Series designed to provide in-depth overviews of the latest epidemiological and statistical methods, as well as advanced coding techniques. These flexible seminars and workshops can be tailored to meet your team’s specific needs, whether through didactic lectures, journal clubs, or interactive examples. We accommodate both large and small groups, offering the convenience of videoconferencing for seamless participation. Our team of leading epidemiologists, statisticians, and software engineers is dedicated to helping you choose the right analytical solutions for your research. Contact us to learn more and elevate your team's expertise with Target RWE's Seminar Series.
Looking to Expand Your Clinical Research Capabilities?
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